MRGPRX1

Reference Set (71 Compounds)

COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1 ZINC000040917971

ZINC000040917971 (search)

O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(CCCN1CCOCC1)Cc1c(Cl)cncc1Cl ZINC000072131721

ZINC000072131721 (search)

Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 ZINC000040917485

ZINC000040917485 (search)

O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1ccco1 ZINC000071318499

ZINC000071318499 (search)

O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccccc1)Cc1ccncc1 ZINC000071316360

ZINC000071316360 (search)

COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1 ZINC000044418871

ZINC000044418871 (search)

O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)Cc1c(Cl)cncc1Cl ZINC000071315917

ZINC000071315917 (search)

Cc1cccc(N2CCN(C(=O)c3ccc4c(c3)nc(-c3cccc(Oc5ccccc5)c3)n4[C@@H](CCCN=C(N)N)C(N)=O)C[C@@H]2C)c1 ZINC000202671920

ZINC000202671920 (search)

O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)C[C@@H]1CCCO1 ZINC000071388877

ZINC000071388877 (search)

$COc1ccccc1C(=O)/C=C1\C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000034630561$

ZINC000034630561 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(C(N)=O)c2)cc1 ZINC000044418875

ZINC000044418875 (search)

CC[C@@H](C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 ZINC000042804190

ZINC000042804190 (search)

COc1ccc(C(=O)O[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1OC ZINC000038226641

ZINC000038226641 (search)

CCN(Cc1c(Cl)cncc1Cl)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 ZINC000071316301

ZINC000071316301 (search)

$COc1ccccc1[C@@H](O)/C=C1\C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000000598534$

ZINC000000598534 (search)

COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCCNCC5)c(Cl)c4=O)c3C)cc2)cn1 ZINC000044430383

ZINC000044430383 (search)

COCCCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 ZINC000071317786

ZINC000071317786 (search)

$O[C@@H](/C=C1\C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1)c1cccc(C(F)(F)F)c1 ZINC000003791027$

ZINC000003791027 (search)

COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5C[C@H]6C[C@H]5CN6C)c(Cl)c4=O)c3C)cc2)cn1 ZINC000100083893

ZINC000100083893 (search)

CCN(Cc1ccncc1Br)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 ZINC000071318928

ZINC000071318928 (search)

COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCN(C)CC5)c(Cl)c4=O)c3C)cc2)cn1 ZINC000044430432

ZINC000044430432 (search)

O=C(Nc1cccc2ccccc12)O[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000035985098

ZINC000035985098 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1 ZINC000040862271

ZINC000040862271 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccc3ncccc3c2)cc1 ZINC000044308039

ZINC000044308039 (search)

O=C(Nc1ccccc1Cl)O[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000035820521

ZINC000035820521 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccsc2)cc1 ZINC000040916389

ZINC000040916389 (search)

NC(=O)[C@H](CCCN=C(N)N)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCCc3ccccn3)ccc21 ZINC000202672223

ZINC000202672223 (search)

$C(\Cc1ccccc1)=C1\C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000001535852$

ZINC000001535852 (search)

$O[C@@H](/C=C1\C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1)c1ccc(F)cc1 ZINC000003791025$

ZINC000003791025 (search)

CC[C@@H](C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 ZINC000042834951

ZINC000042834951 (search)

CN(CCc1ccccn1)C(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCN=C(N)N)C(N)=O ZINC000202672200

ZINC000202672200 (search)

$Cc1cc(C)cc([C@@H](O)/C=C2\C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)c1 ZINC000001483085$

ZINC000001483085 (search)

N#Cc1cccc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)c1 ZINC000013744490

ZINC000013744490 (search)

FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000036324059

ZINC000036324059 (search)

CCN(Cc1ccncc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 ZINC000071329956

ZINC000071329956 (search)

NC(=O)[C@H](CCCN=C(N)N)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCN(c4ccc(F)cc4)CC3)ccc21 ZINC000202670511

ZINC000202670511 (search)

O=C(O[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1)c1ccccc1C(F)(F)F ZINC000653768981

ZINC000653768981 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc3cccnc23)cc1 ZINC000044351438

ZINC000044351438 (search)

O=C(Nc1cccc([N+](=O)[O-])c1)O[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000136877344

ZINC000136877344 (search)

O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(Cc1ccncc1)CC1CC1 ZINC000071329665

ZINC000071329665 (search)

CNCCNc1cnn(Cc2cccc(NC(=O)c3ccc(-c4ccc(OC)nc4)cc3)c2C)c(=O)c1Cl ZINC000044418821

ZINC000044418821 (search)

NS(=O)(=O)c1ccc(CCNc2ccnc(NCCc3ccc(Cl)cc3)n2)cc1 ZINC000071318505

ZINC000071318505 (search)

CC[C@@H](C)[C@H]1C(=O)Nc2ccc(N3CC[C@H](NC(C)=O)C3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 ZINC000042806462

ZINC000042806462 (search)

CC[C@@H](C)[C@H]1C(=O)Nc2ccc(NCCOCCOCCN)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 ZINC000049850697

ZINC000049850697 (search)

CCN(Cc1ccccc1)C(=O)CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1 ZINC000071329554

ZINC000071329554 (search)

O=C(Nc1ccccc1Cl)O[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000034631117

ZINC000034631117 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccc(N(C)C)c2)cc1 ZINC000044418714

ZINC000044418714 (search)

N=C(N)NCCC[C@@H](C(N)=O)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccc21 ZINC000653670306

ZINC000653670306 (search)

COc1ccccc1NC(=S)N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 ZINC000038255020

ZINC000038255020 (search)

C[C@@H](CN(C)C)NC(=O)C1CCN(S(=O)(=O)c2ccc3nc(NCCc4ccc(Cl)cc4)nc(N4CCCC4)c3c2)CC1 ZINC000071315988

ZINC000071315988 (search)

N#Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 ZINC000000605485

ZINC000000605485 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2cccs2)cc1 ZINC000040916387

ZINC000040916387 (search)

CC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)N4CCN(c5ccc(F)cc5)CC4)ccc3n21 ZINC000042806644

ZINC000042806644 (search)

CCCCNC(=O)c1ccc2c(c1)nc(-c1cccc(Oc3ccccc3)c1)n2[C@@H](CCCN=C(N)N)C(N)=O ZINC000142045614

ZINC000142045614 (search)

NS(=O)(=O)c1ccc(CCNc2nc(NCCc3ccc(Cl)cc3)nc3ccccc23)cc1 ZINC000071316003

ZINC000071316003 (search)

O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N1CCCCC1 ZINC000071318182

ZINC000071318182 (search)

COc1ccc(NC(=O)c2ccc3c(c2)nc(-c2cccc(Oc4ccccc4)c2)n3[C@@H](CCCN=C(N)N)C(N)=O)cc1 ZINC000142045417

ZINC000142045417 (search)

CC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)N4CCN(c5ccc(F)cc5)CC4)ccc3n21 ZINC000044430682

ZINC000044430682 (search)

NC(=O)[C@@H](CCCN=C(N)N)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)N3CCOCC3)ccc21 ZINC000218425498

ZINC000218425498 (search)

CN[C@H]1CCN(c2cnn(Cc3cccc(NC(=O)c4ccc(-c5ccc(OC)nc5)cc4)c3C)c(=O)c2Cl)C1 ZINC000044418722

ZINC000044418722 (search)

CC(=O)N[C@H]1CCN(c2ccc3c(c2)-c2nc4cc(C(=O)N5CCN(c6ccc(F)cc6)CC5)ccc4n2[C@@H](C(C)C)C(=O)N3)C1 ZINC000042806897

ZINC000042806897 (search)

NC(=O)[C@H](CCCN=C(N)N)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)Nc3nccs3)ccc21 ZINC000143716353

ZINC000143716353 (search)

NC(=O)[C@@H](CCCN=C(N)N)n1c(-c2cccc(Oc3ccccc3)c2)nc2cc(C(=O)Nc3ccc4cn[nH]c4c3)ccc21 ZINC000218425688

ZINC000218425688 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)C1CCN(c2ccc(C#N)cc2)CC1 ZINC000042877003

ZINC000042877003 (search)

Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1 ZINC000040863575

ZINC000040863575 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccc(-c2ccsc2)c1 ZINC000040401972

ZINC000040401972 (search)

COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5C[C@H](C)N[C@H](C)C5)c(Cl)c4=O)c3C)cc2)cn1 ZINC000044350816

ZINC000044350816 (search)

COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCN[C@H](C(N)=O)C5)c(Cl)c4=O)c3C)cc2)cn1 ZINC000042803403

ZINC000042803403 (search)

Clc1ccc(CCNc2nc(N3CCCC3)c3ccccc3n2)cc1 ZINC000071330914

ZINC000071330914 (search)

Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1cccc(-c2cccs2)c1 ZINC000040918661

ZINC000040918661 (search)

O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1 ZINC000040391174

ZINC000040391174 (search)